Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
نویسندگان
چکیده
منابع مشابه
Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
Fibroblast growth factor receptor 2 (FGFR2) is a membrane-spanning tyrosine kinase that mediates signaling for FGFs. Recent studies detected various point mutations of FGFR2 in multiple types of cancers, including breast cancer, lung cancer, gastric cancer, uterine cancer and ovarian cancer, yet the casual relationship between these mutations and tumorigenesis is unclear. Here we will discuss p...
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crouzon syndrome is a rare autosomal dominant premature cranyosynostosis, caused by fibroblast growth factor receptor 2 gene mutation on chromosome 10. the predominant skull and facial malformations with potential compromise airway make the crouzon syndrome a demanding issue for anesthesiologists and surgeons, required dynamic team work. in this report we describe a child, a known case of crouz...
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background: genetic factors associated with cancer have been widely investigated and several polymorphisms have been connected with breast cancer. breast cancer (bc) can be considered one of the most popular reasons of death among women. bc, likewise, is the second cause of death in iran. the present research aims at determining the frequency of the fibroblast growth factor receptor (fgfr) gene ...
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BACKGROUND One of the main challenges in skin flap surgery is tissue ischemia and following necrosis. The present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. METHODS Thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal rando...
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ژورنال
عنوان ژورنال: International Journal of Biological Sciences
سال: 2017
ISSN: 1449-2288
DOI: 10.7150/ijbs.20792